Inhibition of Endoplasmic Reticulum Stress Attenuated Ethanol-Induced Exosomal miR-122 and Acute Liver Injury in Mice-Reference-Cited by-同舟云学术

Inhibition of Endoplasmic Reticulum Stress Attenuated Ethanol-Induced Exosomal miR-122 and Acute Liver Injury in Mice

Published:2019-01-09 Issue:5 Volume:54 Page:465-471
ISSN:0735-0414
Container-title:Alcohol and Alcoholism
language:en
Short-container-title:

Author:

Wang Sheng¹²,Luan Jiajie¹,Lv Xiongwen²

Affiliation:

1. Department of Pharmacy, Yijishan Affiliated Hospital of Wannan Medical College, Wuhu, Anhui Province, China

2. The Key Laboratory of Anti-inflammatory and Immune medicines, Ministry of Education, School of Pharmacy, Institute for Liver Disease of Anhui Medical University, Hefei, Anhui Province, China

Abstract

ICR mice received ethanol (5 g/kg) by intragastric administration, showing an increase in hepatosomatic index and ALT. These effects were accompanied by increased expression of ER stress-related proteins and exosomal miR-122, PBA intervention can attenuate these changes induced by ethanol provides a potential therapy strategy for acute alcoholic liver injury.

Funder

National Natural Science Foundation of China

2016 Annual Leading Talent Introduction and Cultivation Project in Universities

Science and Technology Research Project of Anhui Province

Natural Science Foundation of Anhui Province

Publisher

Oxford University Press (OUP)

Subject

General Medicine

Link

http://academic.oup.com/alcalc/article-pdf/54/5/465/30251809/agz058.pdf

Reference45 articles.