Alcohol Craving and Severity are Associated with Dorsal Anterior Cingulate Choline Levels in Individuals with an Alcohol Use Disorder

Author:

Grodin Erica N1,Burnette Elizabeth M12,O’Neill Joseph34,Alger Jeffry5,Ray Lara A164

Affiliation:

1. Department of Psychology, University of California at Los Angeles , Los Angeles, CA

2. Neuroscience Interdepartmental Program, University of California at Los Angeles , Los Angeles, CA

3. Jane & Terry Semel Institute for Neuroscience and Human Behavior, University of California , Los Angeles, CA

4. Brain Research Institute, University of California , Los Angeles, CA

5. Department of Neurology, University of California Los Angeles , MC 708522, Los Angeles, CA

6. Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles , Los Angeles, CA

Abstract

Abstract Aims Magnetic resonance spectroscopy (MRS) has been used to probe inflammation in the brain. While altered MRS metabolite levels have previously been found in individuals with alcohol use disorder (AUD), the relationship between potential metabolite markers of inflammation and the clinical correlates of AUD remains understudied. Therefore, this exploratory study sought to elucidate the clinical significance of inflammation in AUD by examining relationships between metabolites, AUD severity, alcohol consumption, and craving in individuals with AUD. Methods Data for this secondary analysis are derived from a two-week clinical trial of ibudilast to treat AUD. Forty-three non-treatment-seeking individuals with an AUD (26M/17F) completed an MRS scan and alcohol-related questionnaires. MRS was performed using a multi-voxel array placed above the corpus callosum, extending from the pregnenual anterior cingulate to premotor cortex. The dorsal anterior cingulate was selected as the volume of interest. Metabolite levels of choline-compounds (Cho), myo-inositol (mI), and creatine+phosphocreatine (Cr) were quantified. Separate hierarchical regression models were used to evaluate the independent effects of metabolite levels on alcohol craving, alcohol problem severity, and alcohol consumption. Results Dorsal anterior cingulate Cho predicted alcohol craving and alcohol problem severity over and above demographics, medication, and alcohol consumption measures. mI and Cr did not predict alcohol craving or alcohol problem severity. Metabolite markers were not predictive of alcohol consumption. Conclusions This preliminary study indicates that dACC Cho is sensitive to clinical characteristics of AUD. This is a further step in advancing neurometabolites, particularly Cho, as potential biomarkers and treatment targets for AUD.

Funder

National Institute on Drug Abuse

National Institute on Alcohol Abuse and Alcoholism

Publisher

Oxford University Press (OUP)

Subject

General Medicine

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