1. Nottingham Digestive Diseases Biomedical Research Centre (NDDC), School of Medicine, University of Nottingham, Queens Medical Centre Nottingham, Nottingham NG7 2UH, UK
2. NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham NG7 2RD, UK
3. Division of Epidemiology and Public Health, University of Nottingham, Nottingham NG7 2RD, UK