Hyperalgesia after a Drinking Episode in Young Adult Binge Drinkers: A Cross-Sectional Study

Author:

You Dokyoung S1ORCID,Hahn Hunter A1,Welsh Thomas H2,Meagher Mary W1

Affiliation:

1. Department of Psychology, Texas A&M University, 425 Ross Street, College Station, TX 77843-4235, USA

2. Departments of Animal Science and Veterinary Integrative Biosciences, Texas A&M University, 474 Olsen Blvd, College Station, TX 77843-2471, USA

Abstract

Abstract Aims Rodent studies propose potential mechanisms linking excessive drinking and pain hypersensitivity (hyperalgesia), such that stress hormones (i.e. epinephrine and cortisol) mediate induction and maintenance of alcohol withdrawal-induced hyperalgesia. The first aim of this study was to examine whether hyperalgesia would occur within 48 h after a drinking episode in healthy young adult binge drinkers. The second was to examine whether stress hormones and negative effect would be associated with binge drinking or alcohol withdrawal-associated hyperalgesia. Methods A cross-sectional experiment was conducted in five groups with naturally occurring drinking (mean age = 19.6, range 18–29 years): abstainers (n = 43, 54% female), moderate drinkers with (n = 50, 50% female) or without recent drinking (i.e. within 48 h, n = 23, 26% female) and binge drinkers with (n = 36, 58% female) or without recent drinking (n = 25, 44% female). All types of drinkers endorsed drinking about 2–3 times a month and 2–3 years of drinking history. Results Muscle pressure pain thresholds were significantly lower in the binge group with recent drinking compared to other groups, but cutaneous mechanical and heat pain thresholds were not significantly different across the five groups. Basal epinephrine levels were significantly higher in binge groups regardless of recent drinking, but cortisol and negative effect were not significantly different across the five groups. Conclusions This is the first study to show that alcohol withdrawal-associated muscle hyperalgesia may occur in healthy episodic binge drinkers with only 2–3 years of drinking history, and epinephrine may play a role in binge drinking-associated hyperalgesia.

Funder

National Institutes of Health National Research Service

National Institute on Alcohol Abuse and Alcoholism

Dissertation Enhancement

Publisher

Oxford University Press (OUP)

Subject

General Medicine

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