Early monomorphic ventricular tachycardia is associated with increased long-term mortality in STEMI

Abstract

Abstract Background Malignant ventricular arrhythmias occurring early during ST-elevation myocardial infarction (STEMI) are known to markedly contribute to increased in-hospital mortality, but not to influence the long-term prognosis. However recent data advocate differential approach to the type of arrhythmia and indicate long-term hazard of monomorphic ventricular tachycardia (VT). Purpose We aimed to evaluate the prognostic value of monomorphic VT compared to non-monomorphic VT or ventricular fibrillation (VF) during the first 48 hours of STEMI in non-selected cohort of STEMI patients admitted for primary PCI. Methods Consecutive STEMI patients admitted to a tertiary care hospital for primary PCI during 2007–2010 were included. The Swedish national SWEDEHEART registry was used for assessment of clinical characteristics and the presence of VT/VF during index admission. The occurrence and type of VT/VF during the first 48 hours from symptom onset were verified in medical records. Information on all-cause mortality endpoint 8 years after STEMI was obtained from the Swedish Cause of Death Register. Results In total, 2277 patients were included (age 66±12 years, 70% male). Early monomorphic VT during index STEMI was documented in 35 (1.5%) and non-monomorphic VT or VF – in 115 (5.1%) patients. Patients with monomorphic VT had similar clinical characteristics compared to those with non-monomorphic VT/VF with a trend of higher prevalence of history of myocardial infarction by index admission among those with monomorphic VT (31% vs 21%, p=0.256). In total, 22 (63%) patients with monomorphic VT and 43 (37%) with non-monomorphic VT/VF died by 8 years of follow up (p=0.011). Monomorphic VT was associated with a higher risk of all-cause mortality compared to non-monomorphic VT/VF in a univariate analysis (HR 2.03, 95% CI 1.21–3.39, p=0.007) and after adjustment for age and history of myocardial infarction (HR 1.74, 95% CI 1.02–2.97, p=0.041) (Figure). Conclusion Monomorphic VT during the first 48 hours of STEMI is associated with a higher risk of all-cause mortality compared to non-monomorphic VT/VF and deserves further studies in order to refine risk stratification strategies. Survival after STEMI by VT/VF <48 hours Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): The Swedish Heart-Lung Foundation