Affiliation:
1. Department of Anesthesiology, The Second Affiliated Hospital of University of South China, Hengyang 421001, China
2. Department of Anesthesiology, The First Hospital of Hunan University of Chinese Medicine, Changsha 410000, China
3. Department of Anesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China
Abstract
Abstract
Glycogen synthase kinase-3 (GSK-3) is a highly conserved and multifunctional serine/threonine protein kinase widely distributed in eukaryotic cells. GSK-3 is originally thought to be an enzyme that regulates glycogen synthesis. It was subsequently found that GSK-3 influences many critical cellular functions, such as cell structure, neural plasticity, gene expression, and neuronal survival. Recently, GSK-3 has been found to be associated with cognition, and its dysregulation leads to cognitive impairments in many diseases, including Alzheimer’s disease, diabetes, depression, Parkinson’s disease, and others. In this review, we summarized the current knowledge about the structure of GSK-3, the regulation of GSK-3 activity, and its role in cognitive function and cognitive-related disease.
Funder
Hunan Provincial Science and Technology Department
National Natural Science Foundation of China
Publisher
China Science Publishing & Media Ltd.
Subject
General Medicine,Biochemistry,Biophysics
Cited by
28 articles.
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