A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3′-kinase activation and endothelial cell migration-Reference-Cited by-同舟云学术

A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3′-kinase activation and endothelial cell migration

Published:2000-08-01 Issue:15 Volume:19 Page:4064-4073
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:

Author:

Gille Hendrik¹,Kowalski Joe²,Yu Lanlan²,Chen Helen²,Pisabarro M.Teresa³,Davis-Smyth Terri⁴,Ferrara Napoleone²

Affiliation:

1. Present address: Xantos Biomedicine; D-82152 Martinsried Germany

2. Departments of Molecular Oncology; South San Francisco CA 94080 USA

3. Protein Engineering, Genentech, Inc., 1 DNA Way; South San Francisco CA 94080 USA

4. Present address: Raven Biotechnologies, Inc.; San Carlos CA 94070 USA

Publisher

Wiley

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Reference52 articles.

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3. The vascular endothelial growth factor receptor Flt-1 mediates biological activities. Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis;Clauss;J Biol Chem,1996

4. Interaction of the Flt-1 tyrosine kinase receptor with the p85 subunit of phosphatidylinositol 3-kinase. Mapping of a novel site involved in binding;Cunningham;J Biol Chem,1995

5. The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade;Davis-Smyth;EMBO J,1996

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