Affiliation:
1. Department of Surgery, University of Cambridge , Cambridge , UK
Abstract
A major restriction to transplantation is the requirement for ABO blood group compatibility between donor and recipient. In this study, an α-galactosidase enzyme from Bacteroides fragilis was used successfully to remove type B blood group antigens enzymatically from human kidneys using ex vivo normothermic machine perfusion. This provides the first step for a strategy to overcome the ABO barrier in kidney transplantation.
Funder
National Institute for Health Research
Blood and Transplant Research Unit
University of Cambridge
Newcastle University
NHS Blood and Transplant
Publisher
Oxford University Press (OUP)
Cited by
11 articles.
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