Benchmarking of minimally invasive distal pancreatectomy with splenectomy: European multicentre study

Author:

Giani Alessandro12ORCID,van Ramshorst Tess23,Mazzola Michele1ORCID,Bassi Claudio4,Esposito Alessandro4,de Pastena Matteo4ORCID,Edwin Bjørn5,Sahakyan Mushegh5ORCID,Kleive Dyre5,Jah Asif6,van Laarhoven Stijn6,Boggi Ugo7ORCID,Kauffman Emanuele Federico7,Casadei Riccardo8,Ricci Claudio8,Dokmak Safi9ORCID,Ftériche Fadhel Samir9,White Steven A10,Kamarajah Sivesh K10ORCID,Butturini Giovanni11,Frigerio Isabella11,Zerbi Alessandro1213,Capretti Giovanni1213,Pando Elizabeth14,Sutcliffe Robert P15,Marudanayagam Ravi15,Fusai Giuseppe Kito16,Fabre Jean Michel17,Björnsson Bergthor18ORCID,Timmermann Lea19ORCID,Soonawalla Zahir20,Burdio Fernando21,Keck Tobias22,Hackert Thilo23ORCID,Groot Koerkamp Bas24ORCID,d’Hondt Mathieu25,Coratti Andrea26,Pessaux Patrick27,Pietrabissa Andrea28,Al-Sarireh Bilal29,Marino Marco V3031ORCID,Molenaar Quintus32,Yip Vincent33,Besselink Marc3,Ferrari Giovanni1,Hilal Mohammad Abu2,

Affiliation:

1. Division of Minimally Invasive Surgical Oncology, ASST Grande Ospedale Metropolitano Niguarda , Milan , Italy

2. Department of General Surgery, Istituto Ospedaliero Fondazione Poliambulanza , Brescia , Italy

3. Department of Surgery, Amsterdam UMC, University of Amsterdam, Cancer Centre Amsterdam , Amsterdam , the Netherlands

4. Department of Surgery, Pancreas Institute, Verona University Hospital , Verona , Italy

5. Intervention Centre and Department of Hepatopancreatobiliary Surgery, Oslo University Hospital and Institute of Medicine, University of Oslo , Oslo Norway

6. Department of Surgery, Cambridge University Hospitals NHS Foundation Trust , Cambridge , UK

7. Department of Surgery, University Hospital of Pisa , Pisa , Italy

8. Department of Surgery, Sant’Orsola Malpighi Hospital , Bologna , Italy

9. Department of Hepatopancreatobiliary Surgery and Liver Transplantation, Beaujon Hospital , Clichy , France

10. Department of Surgery, Freeman Hospital Newcastle upon Tyne , Newcastle upon Tyne , UK

11. Department of Surgery, Pederzoli Hospital , Peschiera , Italy

12. Department of Biomedical Sciences, Humanitas University , Pieve Emanuele , Italy

13. IRCCS Humanitas Research Hospital , Rozzano , Italy

14. Department of Surgery, Vall d’Hebron University Hospital , Barcelona , Spain

15. Department of Hepatopancreatobiliary Surgery, University Hospitals Birmingham NHS Foundation Trust , Birmingham , UK

16. Hepatopancreatobiliary and Liver Transplant Unit, Royal Free London , London , UK

17. Department of Surgery, Saint-Éloi Hospital , Montpellier , France

18. Department of Surgery in Linköping and Department of Biomedical and Clinical Sciences, Linköping University , Linköping , Sweden

19. Department of Surgery, Charité , Berlin , Germany

20. Department of Surgery, Oxford University Hospital , Oxford , UK

21. Department of Surgery, University Hospital del Mar , Barcelona , Spain

22. Department of Surgery, University Medical Centre Schleswig-Holstein , Campus Lübeck, Lübeck , Germany

23. Department of Surgery, Heidelberg University Hospital , Heidelberg , Germany

24. Department of Surgery, Erasmus Medical Centre , Rotterdam, the Netherlands

25. Department of Digestive and Hepatobiliary/Pancreatic Surgery, Groeninge Hospital , Kortrijk , Belgium

26. Division of Oncological and Robotic General Surgery, Careggi University Hospital , Florence , Italy

27. Division of Hepato-Biliary and Pancreatic Surgery, Nouvel Hôpital Civil, University Hospital, Institut Hospitalo-Universitaire de Strasbourg , Strasbourg , France

28. Department of Surgery, Fondazione IRCCS Policlinico San Matteo , Pavia , Italy

29. Department of Surgery, Morriston Hospital , Swansea , UK

30. General and Emergency Surgery Department, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello , Palermo , Italy

31. General Surgery Department, Istituto Villa Salus , Siracusa , Italy

32. Department of Surgery, UMC Utrecht Cancer Centre, University Medical Centre Utrecht , Utrecht , the Netherlands

33. Department of Hepatopancreatobiliary Surgery, Royal London Hospital, Barts Health NHS Trust , London , UK

Abstract

Abstract Background Benchmarking is the process to used assess the best achievable results and compare outcomes with that standard. This study aimed to assess best achievable outcomes in minimally invasive distal pancreatectomy with splenectomy (MIDPS). Methods This retrospective study included consecutive patients undergoing MIDPS for any indication, between 2003 and 2019, in 31 European centres. Benchmarks of the main clinical outcomes were calculated according to the Achievable Benchmark of Care (ABC™) method. After identifying independent risk factors for severe morbidity and conversion, risk-adjusted ABCs were calculated for each subgroup of patients at risk. Results A total of 1595 patients were included. The ABC was 2.5 per cent for conversion and 8.4 per cent for severe morbidity. ABC values were 160 min for duration of operation time, 8.3 per cent for POPF, 1.8 per cent for reoperation, and 0 per cent for mortality. Multivariable analysis showed that conversion was associated with male sex (OR 1.48), BMI exceeding 30 kg/m2 (OR 2.42), multivisceral resection (OR 3.04), and laparoscopy (OR 2.24). Increased risk of severe morbidity was associated with ASA fitness grade above II (OR 1.60), multivisceral resection (OR 1.88), and robotic approach (OR 1.87). Conclusion The benchmark values obtained using the ABC method represent optimal outcomes from best achievable care, including low complication rates and zero mortality. These benchmarks should be used to set standards to improve patient outcomes.

Publisher

Oxford University Press (OUP)

Subject

Surgery

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