DESIGN AND STUDY OF DIFFERENT PVDF STRUCTURES

Abstract

Abstract Introduction Tissue engineering (TE) is a promising technology that can develop structures very similar to native tissues to improve or replace their biological functions. Polyvinylidene fluoride (PVDF) is a new thermoplastic polymer widely used in biomedical applications. Each structure of PVDF has different mechanical and biological characteristics depending on its morphology and the methodology employed. Methods Doctor blade, salt leaching, and electrospinning methodologies were used to design different PVDF structures, including films, porous membranes, and electrospun membranes, respectively. Furthermore, electrospun PVDF membranes were developed according to the direction of the strands, obtaining membranes that were oriented as well as with random orientation. All these morphologies were subjected to mechanical, cytotoxicity and degradation studies. Results All PVDF morphologies underwent a minimum modification of 16% with respect to their original size. The porous membranes were the most fragile structures, and the electrospun membranes were the most resistant. According to ISO standard 10993–5, a material is considered to be biocompatible when the values are higher than 70%, and all PVDF morphologies had cell viability values above the 70% threshold. Finally, results showed that there was no degradability, regardless of the method or structure designed. Conclusions PVDF is a material with good mechanical characteristics, given that structures designed with electrospinning can withstand more stress. In addition, this material is non-degradable and biocompatible, broadening the range of biomedical and TE applications.