Targeted anti-interleukin-17 therapy for linear porokeratosis-Reference-Cited by-同舟云学术

Targeted anti-interleukin-17 therapy for linear porokeratosis

Published:2023-07-05 Issue:5 Volume:189 Page:630-631
ISSN:0007-0963
Container-title:British Journal of Dermatology
language:en
Short-container-title:

Author:

Li Donglin¹^ORCID,Technau-Hafsi Kristin¹,Giehl Katrin²,Hoeger Peter H³,Has Cristina¹^ORCID

Affiliation:

1. Department of Dermatology, Medical Center – University of Freiburg , Freiburg , Germany

2. Department of Dermatology, Ludwig Maximilian University of Munich , Munich , Germany

3. Catholic Children’s Hospital , Wilhelmstift, Hamburg , Germany

Abstract

We report a case involving a 12-year-old female patient with linear porokeratosis (LP) associated with the PMVK pathogenic variant c.329C>A, p.R110Q (monoallelic in DNA from blood and biallelic in DNA from LP). Therapeutic measures, which included a statin/cholesterol cream, did not ameliorate the patient’s skin lesions. Our findings demonstrate a strong interleukin (IL)-17A-positive inflammatory infiltrate, upregulation of IL-17-responsive genes and a significant clinical response to anti-IL-17A therapy in LP.

Publisher

Oxford University Press (OUP)

Subject

Dermatology

Link

https://academic.oup.com/bjd/advance-article-pdf/doi/10.1093/bjd/ljad223/51091919/ljad223.pdf

Reference8 articles.

1. Second-hit, postzygotic PMVK and MVD mutations in linear porokeratosis;Atzmony;JAMA Dermatol,2019

2. Molecular characterization and natural history of linear porokeratosis: a case series;Saleva-Stateva;J Am Acad Dermatol,2021

3. Functional evaluation of conserved basic residues in human phosphomevalonate kinase;Herdendorf;Biochemistry,2007

4. Lack of effect of topical statins in linear porokeratosis;Saleva-Stateva;J Eur Acad Dermatol Venereol,2021

5. Topical cholesterol/lovastatin for the treatment of porokeratosis: a pathogenesis-directed therapy;Atzmony;J Am Acad Dermatol,2020

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