Efficacy and safety of roflumilast cream for chronic plaque psoriasis with facial/neck and intertriginous area involvement: a post hoc analysis from a randomized controlled trial

Author:

Draelos Zoe D1,Adam David N2,Hong H Chih-ho3,Lebwohl Mark G4,Lynde Charles W5,Nahm Walter K6,Papp Kim A7ORCID,Pariser David M8,Stein Gold Linda9,Stewart Daniel10,Higham Robert C11,Berk David R11,Krupa David11,Burnett Patrick11

Affiliation:

1. Dermatology Consulting Services , High Point, NC , USA

2. CCA Medical Research, Probity Medical Research and Temerty Faculty of Medicine, University of Toronto , Toronto, ON , Canada

3. Department of Dermatology and Skin Science, University of British Columbia and Probity Medical Research , Surrey, BC , Canada

4. Icahn School of Medicine at Mount Sinai , New York, NY , USA

5. University of Toronto, Toronto, Lynde Centre for Dermatology, Markham, and Probity Medical Research , Markham, ON , Canada

6. University of California, San Diego, School of Medicine , San Diego, CA , USA

7. Probity Medical Research and K Papp Clinical Research , Waterloo, ON , Canada

8. Eastern Virginia Medical School and Virginia Clinical Research , Inc., Norfolk, VA , USA

9. Henry Ford Medical Center , Detroit, MI , USA

10. Michigan Center for Skin Care Research , Clinton Township, MI , USA

11. Arcutis, Inc. , Westlake Village, CA , USA

Abstract

This post hoc analysis evaluated efficacy and safety of roflumilast cream in patients with psoriasis involving the face/neck or intertriginous areas from a phase IIb trial. Of 331 patients enrolled in the phase IIb trial, 160 had psoriasis involving the face/neck and/or intertriginous areas. Once-daily roflumilast cream was well tolerated with efficacy across multiple endpoints in these patients.

Funder

Arcutis Biotherapeutics, Inc

Publisher

Oxford University Press (OUP)

Subject

Dermatology

Reference8 articles.

1. Psoriasis in special localizations;Dopytalska;Reumatologia,2018

2. Joint AAD-NPF Guidelines of care for the management and treatment of psoriasis with topical therapy and alternative medicine modalities for psoriasis severity measures;Elmets;J Am Acad Dermatol,2021

3. Treatment of inverse/intertriginous psoriasis: updated guidelines from the Medical Board of the National Psoriasis Foundation;Khosravi;J Drugs Dermatol,2017

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