Integrative serum proteomics analysis reveals distinct immune and cardiovascular profile dysregulation in erythrodermic psoriasis-Reference-Cited by-同舟云学术

Integrative serum proteomics analysis reveals distinct immune and cardiovascular profile dysregulation in erythrodermic psoriasis

Published:2023-08-16 Issue:6 Volume:189 Page:769-771
ISSN:0007-0963
Container-title:British Journal of Dermatology
language:en
Short-container-title:

Author:

Song Biao¹²³^ORCID,Wu Chao¹²³^ORCID,Liu Weida²⁴^ORCID,Wang Yanan¹²³^ORCID,Ning Xin¹²³^ORCID,Guo Lan¹²³^ORCID,Liu Xiaohan¹²³^ORCID,Gao Yimeng¹²³,Jin Hongzhong¹²³^ORCID

Affiliation:

1. Department of Dermatology Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing , China

2. State Key Laboratory of Complex Severe and Rare Diseases , Beijing , China

3. National Clinical Research Center for Dermatologic and Immunologic Diseases , Beijing , China

4. Medical Research Center,Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing , China

Abstract

In-depth analysis of circulating proteome alterations identified that erythrodermic psoriasis (EP) presented a dysregulated serum proteome with distinct inflammation elevation, immune activation and metabolic disturbance. We found that EP harboured a blended immune milieu with distinct T helper (Th)17/Th1 skewing and mild Th2 activation. Additionally, atherosclerosis signalling were substantially increased in EP.

Funder

National High-Level Hospital Clinical Research Funding

National Key R&D Program of China

Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences

Publisher

Oxford University Press (OUP)

Subject

Dermatology

Link

https://academic.oup.com/bjd/advance-article-pdf/doi/10.1093/bjd/ljad283/51605920/ljad283.pdf

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