1. Universidad Espiritu Santo , Samborondon 0901952 , Ecuador
2. Respiralab Research Group , Guayaquil , Ecuador
3. Department of Dermatology, Bispebjerg Hospital, University of Copenhagen , Copenhagen , Denmark
4. Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Hospital del Mar, Institut Mar d’Investigacions Mediques, Universitat Autònoma , Barcelona , Spain