Successful dose reduction of dupilumab in atopic dermatitis-Reference-Cited by-同舟云学术

Successful dose reduction of dupilumab in atopic dermatitis

Published:2023-01-20 Issue:5 Volume:188 Page:678-679
ISSN:0007-0963
Container-title:British Journal of Dermatology
language:en
Short-container-title:

Author:

Ardern-Jones Michael R¹²^ORCID,Buchanan Emily E²,Njungu Samba¹,O’Driscoll Daniel¹

Affiliation:

1. Department of Dermatology, University Hospital Southampton NHS Foundation Trust

2. Clinical Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton , Hampshire SO16 1DU , UK

Abstract

Current UK, European and USA atopic dermatitis guidelines do not currently advise on the possibility of dose reduction of dupilumab therapy below the licensed dose of 300 mg subcutaneously every 2 weeks for adults. Here, we report preliminary findings to suggest that in those who respond well to the licensed dose, dupilumab dosing can be reduced while maintaining good disease control. We propose a randomized controlled clinical trial to further analyse the cost effectiveness of this approach.

Publisher

Oxford University Press (OUP)

Subject

Dermatology

Link

https://academic.oup.com/bjd/advance-article-pdf/doi/10.1093/bjd/ljad011/49178991/ljad011.pdf

Reference8 articles.

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3. ; American Academy of Dermatology. Guidelines of care for the management of atopic dermatitis: section 3. Management and treatment with phototherapy and systemic agents;Sidbury;J Am Acad Dermatol,2014

4. ; European Task Force on Atopic Dermatitis/EADV Eczema Task Force. ETFAD/EADV Eczema Task Force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children;Wollenberg;J Eur Acad Dermatol Venereol,2020

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