Statin use and risk of cutaneous melanoma: a nationwide nested case–control study

Author:

Ghiasvand Reza123ORCID,Berge Leon A M134ORCID,Andreassen Bettina K1ORCID,Green Adele C56ORCID,Al Rahmoun Marie7ORCID,Fournier Agnès7ORCID,Kvaskoff Marina7ORCID,Veierød Marit B4ORCID,Robsahm Trude E  13ORCID

Affiliation:

1. Department of Research, Cancer Registry of Norway , Oslo , Norway

2. Oslo Centre for Biostatistics and Epidemiology

3. Institute for Cancer Research

4. Oslo Centre for Biostatistics and Epidemiology, Department of Biostatistics, Institute of Basic Medical Sciences; University of Oslo , Norway

5. QIMR Berghofer Medical Research Institute , Brisbane , Australia

6. CRUK Manchester Institute, University of Manchester , Manchester , UK

7. Université Paris-Saclay, UVSQ, Univ. Paris-Sud , Inserm, Gustave Roussy, ‘Exposome and Heredity’ team, CESP, F-94805, Villejuif , France

Abstract

This nationwide nested case–control study examined the association between statin use and risk of cutaneous melanoma. We included 12 048 adult patients with melanoma and 117 895 randomly selected cancer-free controls, matched on age and sex. Cancer data were obtained from the Cancer Registry of Norway and data on drug use was retrieved from the Norwegian Prescription Database. We estimated rate ratios with 95% confidence intervals and conducted sensitivity analyses. We observed an inverse dose–response association between statin use and melanoma risk, stronger in women. The highest statin intake was associated with a reduced risk of melanoma, particularly on the head/neck and lower limbs. Our finding may have implications for melanoma prevention in high-risk groups.

Funder

South-Eastern Norway Regional Health Authority

Publisher

Oxford University Press (OUP)

Subject

Dermatology

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