Has the time come to assess small-molecule/biologic drug combinations for the management of moderate-to-severe hidradenitis suppurativa?

Author:

Maronese Carlo Alberto12ORCID,Ingram John R3ORCID,Marzano Angelo V12ORCID

Affiliation:

1. Dermatology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico , Milan , Italy

2. Department of Pathophysiology and Transplantation, Università degli Studi di Milano , Milan , Italy

3. Division of Infection and Immunity, Cardiff University , Cardiff , UK

Abstract

As the landscape for hidradenitis suppurativa (HS) medical treatment is rapidly expanding, seemingly taking the same steps that marked the evolution of psoriasis management, upcoming agents still do not appear to offer complete disease control. Better control of severe cases of HS refractory to biologic monotherapy may require investigation of pathogenesis-driven, combination regimens sooner rather than later.

Publisher

Oxford University Press (OUP)

Subject

Dermatology

Reference6 articles.

1. Secukinumab in moderate-to-severe hidradenitis suppurativa (SUNSHINE and SUNRISE): week 16 and week 52 results of two identical, multicentre, randomised, placebo-controlled, double-blind phase 3 trials;Kimball;Lancet,2023

2. Modulation of disease-associated pathways in hidradenitis suppurativa by the Janus kinase 1 inhibitor povorcitinib: transcriptomic and proteomic analyses of two phase 2 studies;Liu;Int J Mol Sci,2023

3. Insights into hidradenitis suppurativa;van Straalen;J Allergy Clin Immunol,2022

4. Successful treatment of hidradenitis suppurativa and Crohn’s disease with combined guselkumab and apremilast;Agud-Dios;Dermatol Ther,2022

5. Oral surveillance and JAK inhibitor safety: the theory of relativity;Winthrop;Nat Rev Rheumatol,2022

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