Stimulating hypocretin receptors improves sleepiness and vigilance in idiopathic hypersomnia: lessons from a proof of concept study
Author:
Affiliation:
1. National Reference Center for Narcolepsy and Rare Hypersomnias, Sleep Clinic, Pitie-Salpetriere Hospital, APHP-Sorbonne University , Paris , France
Publisher
Oxford University Press (OUP)
Subject
Physiology (medical),Neurology (clinical)
Link
https://academic.oup.com/sleep/advance-article-pdf/doi/10.1093/sleep/zsad085/50887778/zsad085.pdf
Reference12 articles.
1. Safety and pharmacodynamics of a single infusion of danavorexton in adults with idiopathic hypersomnia;Mignot,2023
2. Orexin 2 receptor-selective agonist danavorexton improves narcolepsy phenotype in a mouse model and in human patients;Evans;Proc Natl Acad Sci U S A.,2022
3. Orexin 2 receptor-selective agonist danavorexton (TAK-925) promotes wakefulness in non-human primates and healthy individuals;Evans;J Sleep Res.,2023
4. Clinical considerations for the diagnosis of idiopathic hypersomnia;Dauvilliers;Sleep Med Rev.,2022
5. Precision medicine for idiopathic hypersomnia;Arnulf;Sleep Med Clin.,2022
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1. Idiopathic hypersomnia and Kleine–Levin syndrome;Revue Neurologique;2023-10
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