Sleep profile predicts the cognitive decline of mild-moderate Alzheimer’s disease patients

Author:

Targa Adriano D S12ORCID,Benítez Iván D12ORCID,Dakterzada Faridé3,Carnes Anna3,Pujol Montse1,Jorge Carmen3,Minguez Olga1,Dalmases Mireia12,Sánchez-de-la-Torre Manuel24ORCID,Barbé Ferran12,Piñol-Ripoll Gerard3ORCID

Affiliation:

1. Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova-Santa Maria, IRBLleida, Lleida, Spain

2. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain

3. Unitat Trastorns Cognitius, Clinical Neuroscience Research, Santa Maria University Hospital, IRBLleida, Lleida, Spain

4. Grupo de Medicina de Precisión en Enfermedades Crónicas, IRBLleida, Lleida, Spain

Abstract

Abstract Study Objectives To investigate the association between sleep and cognitive decline of patients with mild-moderate Alzheimer’s disease. Methods Observational, prospective study, including consecutive patients diagnosed with mild-moderate Alzheimer’s disease. Cerebrospinal fluid was collected for amyloid-beta, total-tau, and phospho-tau levels determination. Also, overnight polysomnography was performed, followed by neuropsychological evaluations at baseline and after 12 months of follow-up. Principal component analysis revealed two profiles of patients in terms of sleep: one with a propensity to deepen the sleep (deep sleepers) and the other with a propensity to spend most of the time in the lighter sleep stage (light sleepers). Results The cohort included 125 patients with a median [IQR] of 75.0 [72.0;80.0] years. Deep and light sleepers did not present differences in relation to the cerebrospinal fluid pathological markers and to the cognitive function at the baseline. However, there was a significant difference of −1.51 (95% CI: −2.43 to −0.59) in the Mini-mental state examination after 12 months of follow-up. Accordingly, sleep depth and cognitive decline presented a dose–response relationship (p-for-trend = 0.02). Similar outcomes were observed in relation to the processing speed (Stroop words test, p-value = 0.016) and to the executive function (Verbal fluency test, p-value = 0.023). Conclusions Considering the increased cognitive decline presented by light sleepers, the sleep profile may have a predictive role in relation to the cognitive function of patients with mild-moderate Alzheimer’s disease. The modifiable nature of sleep sets this behavior as a possible useful intervention to prevent a marked cognitive decline. Clinical Trial Information Role of Hypoxia Ans Sleep Fragmentation in Alzheimer’s Disease. and Sleep Fragmentation. Completed. NCT02814045

Funder

Departament de Salut, Generalitat de Catalunya

Fundació La Marató TV3

Agency for Management of University and Research Grants

Publisher

Oxford University Press (OUP)

Subject

Physiology (medical),Clinical Neurology

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