Influence of sex hormone use on sleep architecture in a transgender cohort

Author:

Morssinkhof Margot W L1234ORCID,van der Werf Ysbrand D56,van den Heuvel Odile A156,van den Ende Daan A7,van der Tuuk Karin8,den Heijer Martin24ORCID,Broekman Birit F P139

Affiliation:

1. Department of Psychiatry, Amsterdam UMC, Location Vrije Universiteit Amsterdam , The Netherlands

2. Department of Endocrinology and Metabolism, Amsterdam UMC, Location Vrije Universiteit Amsterdam , The Netherlands

3. Department of Psychiatry and Medical Psychology, OLVG , Amsterdam , The Netherlands

4. Center of Expertise on Gender Dysphoria, Amsterdam UMC, Vrije Universiteit Amsterdam , The Netherlands

5. Department of Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam , Amsterdam , The Netherlands

6. Amsterdam Neuroscience, Compulsivity Impulsivity and Attention , Amsterdam , The Netherlands

7. Remote Patient Monitoring & Chronic Care, Philips , Eindhoven , The Netherlands

8. Department of Obstetrics and Gynecology, University Medical Centre Groningen , Groningen , The Netherlands

9. Amsterdam Public Health, Mental Health Program , Amsterdam , The Netherlands

Abstract

Abstract Study Objectives Sex differences in sleep architecture are well-documented, with females experiencing longer total sleep time, more slow wave sleep (SWS), and shorter Rapid Eye Movement (REM) sleep duration than males. Although studies imply that sex hormones could affect sleep, research on exogenous sex hormones on sleep architecture is still inconclusive. This study examined sleep architecture changes in transgender individuals after 3 months of gender-affirming hormone therapy (GAHT). Methods We assessed sleep architecture in 73 transgender individuals: 38 transmasculine participants who started using testosterone and 35 transfeminine participants who started using estrogens and antiandrogens. Sleep architecture was measured before GAHT and after 3 months of GAHT for 7 nights using an ambulatory single-electrode sleep EEG device. Changes in sleep architecture were analyzed using linear mixed models, and non-normally distributed outcomes were log-transformed and reported as percentages. Results In transmasculine participants, SWS decreased by 7 minutes (95% CI: −12; −3) and 1.7% (95% CI: −3%; −0.5%), REM sleep latency decreased by 39% (95% CI: −52%; −22%) and REM sleep duration increased by 17 minutes (95% CI: 7; 26) after 3 months of GAHT. In transfeminine participants, sleep architecture showed no significant changes after 3 months of GAHT. Conclusions Sleep architecture changes after 3 months of masculinizing GAHT in line with sleep in cisgender males, while it shows no changes after feminizing GAHT. The sex-specific nature of these changes raises new questions about sex hormones and sleep. Future research should focus on studying possible underlying neural mechanisms and clinical consequences of these changes.

Publisher

Oxford University Press (OUP)

Subject

Physiology (medical),Neurology (clinical)

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3