Dynamic modulation of theta–gamma coupling during rapid eye movement sleep

Author:

Bandarabadi Mojtaba12ORCID,Boyce Richard3,Gutierrez Herrera Carolina12,Bassetti Claudio L12,Williams Sylvain3,Schindler Kaspar12,Adamantidis Antoine12ORCID

Affiliation:

1. Center for Experimental Neurology, Department of Neurology, Inselspital University Hospital, University of Bern, Bern, Switzerland

2. Department for BioMedical Research, University of Bern, Bern, Switzerland

3. Department of Psychiatry, McGill University, Montreal, Quebec, Canada

Abstract

Abstract Theta phase modulates gamma amplitude in hippocampal networks during spatial navigation and rapid eye movement (REM) sleep. This cross-frequency coupling has been linked to working memory and spatial memory consolidation; however, its spatial and temporal dynamics remains unclear. Here, we first investigate the dynamics of theta–gamma interactions using multiple frequency and temporal scales in simultaneous recordings from hippocampal CA3, CA1, subiculum, and parietal cortex in freely moving mice. We found that theta phase dynamically modulates distinct gamma bands during REM sleep. Interestingly, we further show that theta–gamma coupling switches between recorded brain structures during REM sleep and progressively increases over a single REM sleep episode. Finally, we show that optogenetic silencing of septohippocampal GABAergic projections significantly impedes both theta–gamma coupling and theta phase coherence. Collectively, our study shows that phase-space (i.e. cross-frequency coupling) coding of information during REM sleep is orchestrated across time and space consistent with region-specific processing of information during REM sleep including learning and memory.

Funder

Human Frontier Science Program

Inselspital University Hospital, the University of Bern, Swiss National Science Foundation

European Research Council

Publisher

Oxford University Press (OUP)

Subject

Physiology (medical),Neurology (clinical)

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