Daytime napping is associated with retinal microcirculation: a large population-based study in China-Reference-Cited by-同舟云学术

Daytime napping is associated with retinal microcirculation: a large population-based study in China

Published:2021-11-20 Issue: Volume: Page:
ISSN:0161-8105
Container-title:Sleep
language:en
Short-container-title:

Author:

Liu Xin¹²,Wang Guowei²³,Wang Xiaoyan²³,Wang Yueye¹²,Min Yan⁴⁵^ORCID,Zhang Janice⁴,Chang Robert T⁶^ORCID,Zhao Xueyin²³,He Wei²³,Moshfeghi Darius M⁶,Lu Ying⁷⁸,Hsing Ann W⁴⁵⁸^ORCID,Yao Ke¹^ORCID,Zhu Shankuan²³^ORCID

Affiliation:

1. Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

2. Chronic Disease Research Institute, The Children’s Hospital, and National Clinical Research Center for Child Health, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

3. Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

4. Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford University, Stanford, CA, USA

5. Department of Epidemiology and Population Health, Stanford School of Medicine, Stanford University, Stanford, CA, USA

6. Department of Ophthalmology, Stanford School of Medicine, Stanford University, Stanford, CA, USA

7. Department of Biomedical Data Science, Stanford School of Medicine, Stanford University, Stanford, CA, USA

8. Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, CA, USA

Abstract

Abstract Study Objectives To investigate the association between daytime napping and retinal microcirculation. Methods This is a cross-sectional study from a prospective population-based cohort. 2,662 participants were recruited after quota sampling. Information on napping was collected through face-to-face interviews. Retinal vascular calibers (RVCs), including central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE), and arterio-to-venous ratio (AVR), were obtained from fundus photography. Multivariate regression and restricted cubic spline curve were performed to determine the association between RVCs and daytime napping duration. Results 56.4% participants reported daytime napping regularly. Compared to no nap, daytime nap was related to higher CRAE, with nap duration of 0.5–1 h showing the most significant association. 0.5–1 h daytime nappers displayed an average of 4.18 µm (95% confidence interval [CI] 2.45–5.91, p < 0.001) wider CRAE than non-nappers after adjustment. No significant association was found between CRVE and daytime napping. Moreover, individuals with 0.5–1 h daytime napping had a lower risk for AVR reduction (odds ratio [OR] 0.70, 95% confidence interval [CI] 0.56–0.86, p = 0.001) than non-nappers. Similar association persisted in non-hypertensive population. Restricted cubic spline indicated a J-shaped relationship between AVR reduction and nap duration. Conclusion Retinal microcirculation was positively associated with self-reported 0.5–1 h daytime napping. Better indicators of retinal microcirculation were probably related to nap duration in a J-shaped manner. Also, the possibly beneficial role of 0.5–1 h daytime napping on retinal microcirculation might be independent of clinically diagnosed vascular diseases.

Funder

Amway

Nutrilite Health Institute Wellness Fund

Cyrus Tang Foundation

Zhejiang University Education Foundation

Hsun K Chou Fund of the Zhejiang University Education Foundation

Zhejiang Province Key Laboratory Fund of China

Publisher

Oxford University Press (OUP)

Subject

Physiology (medical),Neurology (clinical)

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