MoonProt 3.0: an update of the moonlighting proteins database

Author:

Chen Chang12,Liu Haipeng3,Zabad Shadi4,Rivera Nina5,Rowin Emily5,Hassan Maheen5,Gomez De Jesus Stephanie M6,Llinás Santos Paola S6,Kravchenko Karyna7,Mikhova Mariia8,Ketterer Sophia9,Shen Annabel9,Shen Sophia9,Navas Erin10,Horan Bryan10,Raudsepp Jaak9,Jeffery Constance15ORCID

Affiliation:

1. Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA

2. Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA

3. Center for Biomolecular Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA

4. Department of Computer Science, McGill University, Montreal, QC, Canada

5. Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA

6. Universidad de Puerto Rico en Cayey, Cayey, PR 00736, USA

7. Department of Biotechnology and Bioengineering, V. N. Karazin Kharkiv National University, IL 61002, Ukraine

8. Minot State University, Minot, ND 58707, USA

9. Cold Spring Harbor High School, Cold Spring Harbor, NY 11724, USA

10. Northport High School, Northport, NY 11768, USA

Abstract

Abstract MoonProt 3.0 (http://moonlightingproteins.org) is an updated open-access database storing expert-curated annotations for moonlighting proteins. Moonlighting proteins have two or more physiologically relevant distinct biochemical or biophysical functions performed by a single polypeptide chain. Here, we describe an expansion in the database since our previous report in the Database Issue of Nucleic Acids Research in 2018. For this release, the number of proteins annotated has been expanded to over 500 proteins and dozens of protein annotations have been updated with additional information, including more structures in the Protein Data Bank, compared with version 2.0. The new entries include more examples from humans, plants and archaea, more proteins involved in disease and proteins with different combinations of functions. More kinds of information about the proteins and the species in which they have multiple functions has been added, including CATH and SCOP classification of structure, known and predicted disorder, predicted transmembrane helices, type of organism, relationship of the protein to disease, and relationship of organism to cause of disease.

Funder

UIC

Publisher

Oxford University Press (OUP)

Subject

Genetics

Reference30 articles.

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