DNA nanotechnology assisted nanopore-based analysis

Author:

Ding Taoli12,Yang Jing3,Pan Victor45,Zhao Nan3,Lu Zuhong2,Ke Yonggang45,Zhang Cheng1ORCID

Affiliation:

1. Department of Computer Science and Technology, School of Electronics Engineering and Computer Science, Peking University, Beijing 100871, China

2. Department of Biomedical Engineering, College of engineering, Peking University, Beijing 100871, China

3. School of Control and Computer Engineering, North China Electric Power University, Beijing 102206, China

4. Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Emory University School of Medicine, Atlanta, GA 30322, USA

5. Department of Chemistry, Emory University, Atlanta, GA 30322, USA

Abstract

Abstract Nanopore technology is a promising label-free detection method. However, challenges exist for its further application in sequencing, clinical diagnostics and ultra-sensitive single molecule detection. The development of DNA nanotechnology nonetheless provides possible solutions to current obstacles hindering nanopore sensing technologies. In this review, we summarize recent relevant research contributing to efforts for developing nanopore methods associated with DNA nanotechnology. For example, DNA carriers can capture specific targets at pre-designed sites and escort them from nanopores at suitable speeds, thereby greatly enhancing capability and resolution for the detection of specific target molecules. In addition, DNA origami structures can be constructed to fulfill various design specifications and one-pot assembly reactions, thus serving as functional nanopores. Moreover, based on DNA strand displacement, nanopores can also be utilized to characterize the outputs of DNA computing and to develop programmable smart diagnostic nanodevices. In summary, DNA assembly-based nanopore research can pave the way for the realization of impactful biological detection and diagnostic platforms via single-biomolecule analysis.

Funder

National Key Research and Development Program of China

Ministry of Education

Beijing Natural Science Foundation

Beijing Municipal Key R&D Project

Publisher

Oxford University Press (OUP)

Subject

Genetics

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