Author:
,Sweeney Blake A,Petrov Anton I,Ribas Carlos E,Finn Robert D,Bateman Alex,Szymanski Maciej,Karlowski Wojciech M,Seemann Stefan E,Gorodkin Jan,Cannone Jamie J,Gutell Robin R,Kay Simon,Marygold Steven,dos Santos Gil,Frankish Adam,Mudge Jonathan M,Barshir Ruth,Fishilevich Simon,Chan Patricia P,Lowe Todd M,Seal Ruth,Bruford Elspeth,Panni Simona,Porras Pablo,Karagkouni Dimitra,Hatzigeorgiou Artemis G,Ma Lina,Zhang Zhang,Volders Pieter-Jan,Mestdagh Pieter,Griffiths-Jones Sam,Fromm Bastian,Peterson Kevin J,Kalvari Ioanna,Nawrocki Eric P,Petrov Anton S,Weng Shuai,Bouchard-Bourelle Philia,Scott Michelle,Lui Lauren M,Hoksza David,Lovering Ruth C,Kramarz Barbara,Mani Prita,Ramachandran Sridhar,Weinberg Zasha
Abstract
Abstract
RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences that provides a single access point to 44 RNA resources and >18 million ncRNA sequences from a wide range of organisms and RNA types. RNAcentral now also includes secondary (2D) structure information for >13 million sequences, making RNAcentral the world’s largest RNA 2D structure database. The 2D diagrams are displayed using R2DT, a new 2D structure visualization method that uses consistent, reproducible and recognizable layouts for related RNAs. The sequence similarity search has been updated with a faster interface featuring facets for filtering search results by RNA type, organism, source database or any keyword. This sequence search tool is available as a reusable web component, and has been integrated into several RNAcentral member databases, including Rfam, miRBase and snoDB. To allow for a more fine-grained assignment of RNA types and subtypes, all RNAcentral sequences have been annotated with Sequence Ontology terms. The RNAcentral database continues to grow and provide a central data resource for the RNA community. RNAcentral is freely available at https://rnacentral.org.
Funder
Biotechnology and Biological Sciences Research Council
Wellcome Trust
National Institutes of Health
Charles University
Publisher
Oxford University Press (OUP)