FATCAT 2.0: towards a better understanding of the structural diversity of proteins-Reference-Cited by-同舟云学术

FATCAT 2.0: towards a better understanding of the structural diversity of proteins

Published:2020-05-29 Issue:W1 Volume:48 Page:W60-W64
ISSN:0305-1048
Container-title:Nucleic Acids Research
language:en
Short-container-title:

Author:

Li Zhanwen¹,Jaroszewski Lukasz¹,Iyer Mallika²,Sedova Mayya¹,Godzik Adam¹^ORCID

Affiliation:

1. Division of Biomedical Sciences, University of California Riverside School of Medicine, Riverside, CA 92521, USA

2. Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA

Abstract

Abstract FATCAT 2.0 server (http://fatcat.godziklab.org/), provides access to a flexible protein structure alignment algorithm developed in our group. In such an alignment, rotations and translations between elements in the structure are allowed to minimize the overall root mean square deviation (RMSD) between the compared structures. This allows to effectively compare protein structures even if they underwent structural rearrangements in different functional forms, different crystallization conditions or as a result of mutations. The major update for the server introduces a new graphical interface, much faster database searches and several new options for visualization of the structural differences between proteins

Funder

NIH

UCR Institutional Funds

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

http://academic.oup.com/nar/article-pdf/48/W1/W60/33433129/gkaa443.pdf

Reference20 articles.

1. Flexible structure alignment by chaining aligned fragment pairs allowing twists;Ye;Bioinformatics,2003

2. POSA: a user-driven, interactive multiple protein structure alignment server;Li;Nucleic Acids Res.,2014