A randomized controlled trial of two hepatitis A vaccine doses among adolescents with juvenile idiopathic arthritis and Crohn’s disease on immunosuppressive therapy: a pilot study

Author:

Githumbi Racheal1,Kuhn Susan1,Osiowy Carla2,Day Jacqueline2,deBruyn Jennifer C C1,Fritzler Marvin J3,Johnson Nicole A1,Vanderkooi Otto1,Schmeling Heinrike1

Affiliation:

1. Department of Pediatrics, Cumming School of Medicine , University of Calgary, Calgary, Alberta, Canada

2. National Microbiology Laboratory, Public Health Agency of Canada , Winnipeg, Manitoba, Canada

3. Department of Medicine, Cumming School of Medicine , University of Calgary, Calgary, Alberta, Canada

Abstract

This pilot randomized controlled trial assessed the immunogenicity of paediatric vs adult hepatitis A vaccine doses in immunosuppressed adolescents (12–15 years) with juvenile idiopathic arthritis and Crohn’s disease. The study aimed to assess if a single, higher dose provides better immunogenicity, particularly before travel.

Publisher

Oxford University Press (OUP)

Reference9 articles.

1. The response to the inactivated hepatitis A vaccine in children with autoinflammatory diseases: a prospective observational controlled study;Maritsi;Rheumatol Oxf Engl,2016

2. Decreased antibodies against hepatitis A in previously vaccinated treatment naïve juvenile SLE patients: a prospective case control study;Maritsi;Clin Exp Rheumatol,2017

3. Immunogenecity of hepatitis A vaccine in pediatric patients with inflammatory bowel disease;Radzikowski;Inflamm Bowel Dis,2011

4. Immunogenecity of hepatitis A and B vaccination in pediatric patients with inflammatory bowel disease;Urganci;J Pediatr Gastroenterol Nutr,2013

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