1. School of Health Sciences, Faculty of Medicine and Health Sciences, University of Nottingham , Queen’s Medical Centre, Derby Road, Nottingham, NG7 2HA , UK
2. NIHR Nottingham Biomedical Research Centre, Medical School, Queen’s Medical Centre , Derby Road, Nottingham, NG7 2UH , UK
3. NIHR Nottingham Biomedical Research Centre , Medical School, , Derby Road, Nottingham, NG7 2UH , UK
4. Queen’s Medical Centre , Medical School, , Derby Road, Nottingham, NG7 2UH , UK
5. Population Health Sciences Institute , Baddiley-Clark Building, , Newcastleupon-Tyne, NE1 7RU , UK
6. Newcastle University , Baddiley-Clark Building, , Newcastleupon-Tyne, NE1 7RU , UK