A novel fibroblast growth factor-1 ligand with reduced heparin binding protects the heart against ischemia-reperfusion injury in the presence of heparin co-administration

Author:

Huang Chahua12,Liu Yang3,Beenken Andrew3,Jiang Lin4,Gao Xiang4,Huang Zhifeng5,Hsu Anna6,Gross Garrett J.6,Wang Yi-Gang4,Mohammadi Moosa3,Schultz Jo El J.1

Affiliation:

1. Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA;

2. Department of Cardiology, Second Affiliated Hospital, Nanchang University, Nanchang 330006, China;

3. Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA;

4. Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA;

5. School of Pharmacy and Center for Structural Biology, Wenzhou Medical University, Zhejiang 325035, China;

6. Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA

Funder

National Institutes of Health

National Institute of Dental and Craniofacial Research

Natural Science Foundation of China

Publisher

Oxford University Press (OUP)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Reference125 articles.

1. Heart disease and stroke statistics-2016 update: A report from the american heart association;Mozaffarian;Circulation,2016

2. The fgf family: Biology, pathophysiology and therapy;Beenken;Nat Rev Drug Discov,2009

3. Fibroblast growth factors;Ornitz;Genome Biol,2001

4. Biological roles of fibroblast growth factor-2;Bikfalvi;Endocr Rev,1997

5. Identification of a novel fibroblast growth factor, fgf-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain;Yamashita;Biochem Biophys Res Commun,2000

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