Affiliation:
1. Institute of Virology, Helmholtz Centre Munich — German Research Centre for Environmental Health , 85764 Neuherberg, Germany
2. Chair of Microbial Disease Prevention, School of Life Sciences, Technical University of Munich , 85354 Freising, Germany
Abstract
Abstract
The human gut virome is comprised of diverse commensal and pathogenic viruses. The colonization by these viruses begins right after birth through vaginal delivery, then continues through breastfeeding, and broader environmental exposure. Their constant interaction with their bacterial hosts in the body shapes not only our microbiomes but us. In addition, these viruses interact with the immune cells, trigger a broad range of immune responses, and influence different metabolic pathways. Besides its key role in regulating the human gut homeostasis, the intestinal virome contributes to disease development in distant organs, both directly and indirectly. In this review, we will describe the changes in the gut virome through life, health, and disease, followed by discussing the interactions between the virome, the microbiome, and the human host as well as providing an overview of their contribution to gut disease and disease of distant organs.
Funder
German Research Foundation
European Research Council
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Microbiology
Cited by
10 articles.
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