The International Database of Central Arterial Properties for Risk Stratification: Research Objectives and Baseline Characteristics of Participants-Reference-Cited by-同舟云学术

The International Database of Central Arterial Properties for Risk Stratification: Research Objectives and Baseline Characteristics of Participants

Published:2021-09-10 Issue:1 Volume:35 Page:54-64
ISSN:0895-7061
Container-title:American Journal of Hypertension
language:en
Short-container-title:

Author:

Aparicio Lucas S¹²^ORCID,Huang Qi-Fang³^ORCID,Melgarejo Jesus D²^ORCID,Wei Dong-Mei²^ORCID,Thijs Lutgarde²^ORCID,Wei Fang-Fei²⁴^ORCID,Gilis-Malinowska Natasza⁵^ORCID,Sheng Chang-Sheng³^ORCID,Boggia José⁶^ORCID,Niiranen Teemu J⁷⁸^ORCID,Odili Augustine N⁹^ORCID,Stolarz-Skrzypek Katarzyna¹⁰^ORCID,Barochiner Jessica¹^ORCID,Ackermann Daniel¹¹^ORCID,Kawecka-Jaszcz Kalina¹⁰^ORCID,Tikhonoff Valérie¹²^ORCID,Zhang Zhen-Yu²^ORCID,Casiglia Edoardo¹²^ORCID,Narkiewicz Krzysztof⁵^ORCID,Filipovský Jan¹³^ORCID,Schutte Aletta E¹⁴¹⁵^ORCID,Yang Wen-Yi²¹⁶^ORCID,Jula Antti M⁷,Woodiwiss Angela J¹⁷^ORCID,Bochud Murielle¹⁸^ORCID,Norton Gavin R¹⁷^ORCID,Wang Ji-Guang³^ORCID,Li Yan³^ORCID,Staessen Jan A¹⁹²⁰^ORCID,Aparicio L S,Barochiner J,Wei D-M,Melgarejo J D,Thijs L,Staessen J A,Wei F-F,Yang W-Y,Zhang Z-Y,An D W,Cheng Y B,Guo Q H,Huang J F,Huang Q F,Li Y,Sheng C S,Wang J G,Filipovský J,Seidlerová J,Juhanoja E P,Jula A M,Lindroos A S,Niiranen T J,Sivén S S,Casiglia E,Pizzioli A,Tikhonoff V,Chori B S,Danladi B,Odili A N,Oshaju H,Kucharska W,Kunicka K,Gilis-Malinowska N,Narkiewicz K,Sakiewicz W,Swierblewska E,Kawecka-Jaszcz K,Stolarz-Skrzypek K,Rajzer M,Mels C,Kruger R,Mokwatsi G,Schutte A E,Norton G R,Woodiwiss A J,Ackermann D,Bochud M,Ehret G,Álvarez-Vaz R,Américo C,Baccino C,Borgarello L,Florio L,Moliterno P,Noboa A,Noboa O,Olascoaga A,Parnizari P,Pécora M,

Affiliation:

1. Servicio de Clínica Médica, Sección Hipertensión Arterial, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

2. Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium

3. Center for Epidemiological Studies and Clinical Trials and Center for Vascular Evaluations, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

4. Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China

5. Hypertension Unit, Department of Hypertension and Diabetology, Medical University of Gdańsk, Gdańsk, Poland

6. Centro de Nefrología and Departamento de Fisiopatología, Hospital de Clínicas, Universidad de la República, Montevideo, Uruguay

7. Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Turku, Finland

8. Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland

9. Department of Internal Medicine, Faculty of Clinical Sciences, College of Health Sciences, University of Abuja, Abuja, Nigeria

10. First Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College, Kraków, Poland

11. Clinic for Nephrology and Hypertension, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland

12. Department of Medicine, University of Padua, Padua, Italy

13. Faculty of Medicine, Charles University, Pilsen, Czech Republic

14. Hypertension in Africa Research Team (HART), South African Medical Research Council and Unit of Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa

15. School of Population Health, University of New South Wales, The George Institute for Global Health, Sydney, Australia

16. Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

17. Cardiovascular Pathophysiology and Genomics Research Unit, Schools of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

18. Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland

19. Research Institute Alliance for the Promotion of Preventive Medicine, Mechelen, Belgium

20. Biomedical Sciences Group, Faculty of Medicine, University of Leuven, Leuven, Belgium

Abstract

Abstract OBJECTIVE To address to what extent central hemodynamic measurements, improve risk stratification, and determine outcome-based diagnostic thresholds, we constructed the International Database of Central Arterial Properties for Risk Stratification (IDCARS), allowing a participant-level meta-analysis. The purpose of this article was to describe the characteristics of IDCARS participants and to highlight research perspectives. METHODS Longitudinal or cross-sectional cohort studies with central blood pressure measured with the SphygmoCor devices and software were included. RESULTS The database included 10,930 subjects (54.8% women; median age 46.0 years) from 13 studies in Europe, Africa, Asia, and South America. The prevalence of office hypertension was 4,446 (40.1%), of which 2,713 (61.0%) were treated, and of diabetes mellitus was 629 (5.8%). The peripheral and central systolic/diastolic blood pressure averaged 129.5/78.7 mm Hg and 118.2/79.7 mm Hg, respectively. Mean aortic pulse wave velocity was 7.3 m per seconds. Among 6,871 participants enrolled in 9 longitudinal studies, the median follow-up was 4.2 years (5th–95th percentile interval, 1.3–12.2 years). During 38,957 person-years of follow-up, 339 participants experienced a composite cardiovascular event and 212 died, 67 of cardiovascular disease. CONCLUSIONS IDCARS will provide a unique opportunity to investigate hypotheses on central hemodynamic measurements that could not reliably be studied in individual studies. The results of these analyses might inform guidelines and be of help to clinicians involved in the management of patients with suspected or established hypertension.

Funder

Internal Medicine Service, Hospital Italiano de Buenos Aires

European Union

European Research Council

European Research Area Net for Cardiovascular Diseases

National Natural Science Foundation of China

Ministry of Science and Technology

Shanghai Commissions of Science and Technology

Shanghai Municipal Health Commission

Charles University Research Fund

Academy of Finland

Paavo Nurmi Foundation