Inhibitory effects of extracts from <i>Eucalyptus gunnii</i> on α-synuclein amyloid fibrils-Reference-Cited by-同舟云学术

Inhibitory effects of extracts from Eucalyptus gunnii on α-synuclein amyloid fibrils

Published:2024-08-21 Issue: Volume: Page:
ISSN:1347-6947
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

So Masatomo¹²^ORCID,Ono Misaki³,Oogai Shigeki⁴,Kondo Minako⁵,Yamazaki Kaede⁴,Nachtegael Charlotte⁶⁷,Hamajima Hiroshi⁴,Mutoh Risa⁸,Kato Masaki³⁹,Kawate Hisaya³⁹,Oki Tomoyuki³⁹,Kawata Yasushi¹⁰,Kumamoto Shiho³,Tokui Noritaka³⁹¹¹,Takei Toshiki²,Shimizu Kuniyoshi¹²^ORCID,Inoue Akio¹³,Yamamoto Naoki¹⁴,Unoki Motoko¹⁵^ORCID,Tanabe Kenichi³⁹¹¹,Nakashima Kinichi¹⁶,Sasaki Hiroyuki¹⁷,Hojo Hironobu²,Nagata Yasuo⁴,Suetake Isao²³⁹¹¹¹⁷^ORCID

Affiliation:

1. Graduate School of Agriculture, Kyoto University , Kyoto , Japan

2. Institute for Protein Research, Osaka University , Osaka , Japan

3. Department of Nutritional Sciences, Faculty of Nutritional Sciences, Nakamura Gakuen University , Fukuoka , Japan

4. Saga Food & Cosmetic Laboratory, Saga Prefectural Industrial Innovation Center , Saga , Japan

5. ARFS, Hamamatsu University School of Medicine , Shizuoka , Japan

6. Interuniversity Institute of Bioinformatics in Brussels, Université Libre de Bruxelles-Vrije Universiteit Brussel , Brussels , Belgium

7. Machine Learning Group, Université Libre de Bruxelles , Brussels , Belgium

8. Department of Applied Physics, Faculty of Science, Fukuoka University , Fukuoka , Japan

9. Graduate School of Nutritional Sciences, Nakamura Gakuen University , Fukuoka , Japan

10. Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University , Tottori , Japan

11. Institute of Preventive and Medical Dietetics, Nakamura Gakuen University , Fukuoka , Japan

12. Department of Agro-Environmental Sciences, Kyushu University , Fukuoka , Japan

13. Human Brain Research Center, Graduate School of Medicine, Kyoto University , Kyoto , Japan

14. Department of Psychiatry, University of Texas Southwestern Medical Center , Dallas, TX, USA

15. Department of Human Genetics, Graduate School of Medicine, The University of Tokyo , Tokyo , Japan

16. Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University , Fukuoka , Japan

17. Division of Epigenomics and Development, Medical Institute of Bioregulation, Kyushu University , Fukuoka , Japan

Abstract

ABSTRACT Amyloid fibril formation is associated with various amyloidoses, including neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Despite the numerous studies on the inhibition of amyloid formation, the prevention and treatment of a majority of amyloid-related disorders are still challenging. In this study, we investigated the effects of various plant extracts on amyloid formation of α-synuclein. We found that the extracts from Eucalyptus gunnii are able to inhibit amyloid formation, and to disaggregate preformed fibrils, in vitro. The extract itself did not lead to cell damage. In the extract, miquelianin, which is a glycosylated form of quercetin and has been detected in the plasma and the brain, was identified and assessed to have a moderate inhibitory activity, compared to the effects of ellagic acid and quercetin, which are strong inhibitors for amyloid formation. The properties of miquelianin provide insights into the mechanisms controlling the assembly of α-synuclein in the brain.

Funder

Ministry of Education, Culture, Sports, Science and Technology

Osaka University

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/bbb/advance-article-pdf/doi/10.1093/bbb/zbae114/59074573/zbae114.pdf

Reference66 articles.

1. Aggregation-phase diagrams of β2-microglobulin reveal temperature and salt effects on competitive formation of amyloids versus amorphous aggregates;Adachi;J Biol Chem,2018

2. Supersaturation-limited and unlimited phase transitions compete to produce the pathway complexity in amyloid fibrillation;Adachi;J Biol Chem,2015

3. Ellagic acid prevents alpha-synuclein aggregation and protects SH-SY5Y cells from aggregated alpha-synuclein-induced toxicity via suppression of apoptosis and activation of autophagy;Ardah;Int J Mol Sci,2021

4. Ellagic acid prevents α-synuclein aggregation and protects SH-SY5Y cells from aggregated α-synuclein-induced toxicity via suppression of apoptosis and activation of autophagy;Ardah;Int J Mol Sci,2021

5. Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity;Cheng;Nat Chem,2012