Seabuckthorn (<i>Hippophae rhamnoides</i>, L.) pulp oil prevents ultraviolet-induced damage in human fibroblasts-Reference-Cited by-同舟云学术

Seabuckthorn (Hippophae rhamnoides, L.) pulp oil prevents ultraviolet-induced damage in human fibroblasts

Published:2024-05-25 Issue:8 Volume:88 Page:948-955
ISSN:1347-6947
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Okamoto Takuya¹²^ORCID,Nakashima Fumie³,Shibata Takahiro³⁴⁵^ORCID,Mori Daisuke¹²

Affiliation:

1. G ., Gifu , Japan

2. ifu Shellac Manufacturing Co., Ltd ., Gifu , Japan

3. Graduate School of Bioagricultural Sciences, Nagoya University , Nagoya , Japan

4. Institute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University , Nagoya , Japan

5. Institute for Glyco-core Research (iGCORE), Nagoya University , Nagoya , Japan

Abstract

ABSTRACT Seabuckthorn pulp oil (SBO) is used in beauty products because of its rich lipophilic substances with high nutraceutical and cosmeceutical potential. However, the mechanism through which SBO enhances skin elasticity remains unclear. Therefore, in this study, we examined the anti-photoaging activity of SBO in normal human dermal fibroblasts (NHDF) under ultraviolet (UV) irradiation. Pretreatment with SBO significantly suppressed UV-B-induced cell toxicity and collagen degradation, suggesting that SBO contains anti-photoaging substances. Further, palmitoleic acid, the main component of SBO, maintained cell viability and collagen levels in UV-B-irradiated NHDF by suppressing the expression of matrix metalloproteinase 1 and acted on the inhibition of p38 and JNK phosphorylation and nuclear translocation of nuclear factor-kappa B. These findings suggest the utility of SBO as an anti-photoaging agent.

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/bbb/advance-article-pdf/doi/10.1093/bbb/zbae071/58304994/zbae071.pdf

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