Evaluation of quercetin as a potential cytoprotector against acetaldehyde using the cultured hepatocyte model with aldehyde dehydrogenase isozyme deficiency-Reference-Cited by-同舟云学术

Evaluation of quercetin as a potential cytoprotector against acetaldehyde using the cultured hepatocyte model with aldehyde dehydrogenase isozyme deficiency

Published:2024-07-11 Issue: Volume: Page:
ISSN:1347-6947
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Xu Yuhang¹²³,Sawamoto Takeshi⁴,Sun Ruitong¹²³,Ishikura Aki¹²,Munemasa Shintaro¹²⁴^ORCID,Murata Yoshiyuki¹²⁴^ORCID,Satoh Ayano⁵,Matsumoto Akiko⁶,Nakamura Toshiyuki¹²⁴,Nakamura Yoshimasa¹²⁴^ORCID

Affiliation:

1. G , Okayama , Japan

2. raduate School of Environmental and Life Science, Okayama University , Okayama , Japan

3. School of Food Science and Technology, Dalian Polytechnic University , Dalian Liaoning , China

4. Graduate School of Environmental, Life, Natural Science and Technology, Okayama University , Okayama , Japan

5. Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University , Okayama , Japan

6. Department of Social and Environmental Medicine, Saga University , Saga , Japan

Abstract

ABSTRACT Protective effect of quercetin against acetaldehyde was evaluated using the cultured hepatocyte models with aldehyde dehydrogenase (ALDH) isozyme deficiency (aldh2-kd and aldh1a1-kd). The quercetin-induced cytoprotection against acetaldehyde in the ALDH1A1-deficient mutant (aldh1a1-kd) was weaker than that in the wild type. Furthermore, quercetin did not enhance the ALDH activity in aldh1a1-kd cells, suggesting that ALDH1A1 is involved in quercetin-induced cytoprotection.

Funder

MEXT

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/bbb/advance-article-pdf/doi/10.1093/bbb/zbae100/58719475/zbae100.pdf

Reference13 articles.

1. Pathogenesis of alcoholic liver disease: role of oxidative metabolism;Ceni;World J Gastroenterol,2014

2. Alcohol dehydrogenases, aldehyde dehydrogenases, and alcohol use disorders: a critical review;Edenberg;Alcohol Clin Exp Res,2018

3. The microbiota catabolites of quercetin glycosides concertedly enhance the resistance against acetaldehyde-induced oxidative stress;Li;Free Radic Res,2022

4. The role of aldehyde dehydrogenase-1 (ALDH1A1) polymorphisms in harmful alcohol consumption in a Finnish population;Lind;Hum Genomics,2008

5. 3,4-Dihydroxyphenylacetic acid is a potential aldehyde dehydrogenase inducer in murine hepatoma Hepa1c1c7 cells;Liu;Biosci Biotechnol Biochem,2017

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Quercetin Attenuates Acetaldehyde-Induced Cytotoxicity via the Heme Oxygenase-1-Dependent Antioxidant Mechanism in Hepatocytes;International Journal of Molecular Sciences;2024-08-20