Affiliation:
1. Department of Hepatobiliary Surgery, Tianjin First Central Hospital (School of Medicine, Nankai University), Tianjin 300192, China
2. Tianjin Key Laboratory of Organ Transplantation, Tianjin 300192, China
3. The First Central Clinical College of Tianjin Medical University, Tianjin 300192, China
Abstract
Abstract
BACE1 antisense RNA (BACE1-AS) is implicated in promoting cell proliferation in different types of tumors. However, the function and mechanism of BACE1-AS in hepatocellular carcinoma (HCC) are still unclear. In the present study, we found that the relative expression of BACE1-AS in HCC cell lines, HCC tissues, and serum samples of HCC patients was significantly increased, and its high expression was correlated with the poor prognosis of HCC patients. In addition, overexpression of BACE1 promoted HCC cell proliferation, cell cycle progression, migration, and invasion, but inhibited cell apoptosis, while knockdown of BACE1 exerted the opposite role. Furthermore, BACE1-AS sponged miR-214-3p and inhibited its expression, thus promoting Apelin (APLN) expression. Overexpression or knockdown of miR-214-3p could partially reverse the abnormal proliferation, cell cycle progression, migration, invasion, and apoptosis caused by overexpression or knockdown of BACE1. These findings suggest that the BACE1-AS/miR-214-3p/APLN axis is a novel signaling pathway that facilitates HCC.
Funder
Tianjin Science and Technology Plan Project
Publisher
China Science Publishing & Media Ltd.
Subject
General Medicine,Biochemistry,Biophysics
Cited by
12 articles.
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