Role of miR-302/367 cluster in human physiology and pathophysiology-Reference-Cited by-同舟云学术

Role of miR-302/367 cluster in human physiology and pathophysiology

Published:2020-07-07 Issue:8 Volume:52 Page:791-800
ISSN:1745-7270
Container-title:Acta Biochimica et Biophysica Sinica
language:en
Short-container-title:

Author:

Guo Menghuan¹,Gan Lu²³⁴,Si Jing²³⁴,Zhang Jinhua²³⁴,Liu Zhiyuan⁵,Zhao Jin⁶,Gou Zhong⁶,Zhang Hong¹²³⁴

Affiliation:

1. School of Pharmacy, Lanzhou University, Lanzhou 730000, China

2. Bio-Medical Research Center, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China

3. Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou 730000, China

4. School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing 100049, China

5. School of Chemical Engineering, Northwest Minzu University, Lanzhou 730030, China

6. Medical College, Northwest Minzu University, Lanzhou 730030, China

Abstract

Abstract MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate target mRNAs at the post-transcriptional level. Increasing evidence shows the involvement of miRNAs in diverse biological processes. miR-302/367 cluster is highly conserved among vertebrates and made up of five members, including miR-367, miR-302a, miR-302b, miR-302c and miR-302d. miR-302/367 cluster plays an important role in cell proliferation, differentiation and reprogramming, affecting the development of tumor, cardiovascular system, nervous system and immune system. In this review, we will summarize the role of miR-302/367 cluster in embryonic stem cells and induced pluripotent stem cells and try to point out its relationship with tumors, cardiovascular system, nervous system and immune system.

Funder

Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

Ministry of Science and Technology National Key R & D Project

Publisher

China Science Publishing & Media Ltd.

Subject

General Medicine,Biochemistry,Biophysics

Link

http://academic.oup.com/abbs/article-pdf/52/8/791/33641988/gmaa065.pdf

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