Polygenic embryo screening: four clinical considerations warrant further attention

Author:

Pereira S1ORCID,Carmi S2,Altarescu G3ORCID,Austin J4,Barlevy D1,Hershlag A56,Juengst E7,Kostick-Quenet K1,Kovanci E8,Lathi R B9,Mukherjee M110,Van den Veyver I1112,Zuk O13,Lázaro-Muñoz G1415,Lencz T161718

Affiliation:

1. Center for Medical Ethics and Health Policy, Baylor College of Medicine , One Baylor Plaza, MS420, Houston, TX 77030, USA

2. Braun School of Public Health and Community Medicine, The Hebrew University of Jerusalem , Jerusalem, Israel

3. Preimplantation Genetic Unit and lysosomal Clinic, Medical Genetics Institute, Shaare Zedek Medical Center, Hebrew University , Jerusalem, Israel

4. Departments of Psychiatry and Medical Genetics, University of British Columbia , Vancouver, BC, Canada

5. Renaissance School of Medicine, Stony Brook University , Stony Brook, NY, USA

6. Zucker School of Medicine, Hofstra University , Hempstead, NY, USA

7. Center for Bioethics, University of North Carolina at Chapel Hill , Chapel Hill, NC, USA

8. Houston Assisted Reproductive Technologies (HART) Fertility Clinic , The Woodlands, TX, USA

9. Stanford University , Stanford, CA, USA

10. University of Califorinia, Berkeley Department of Sociology, , Berkeley, CA 94720 USA

11. Department of Obstetrics and Gynecology, Baylor College of Medicine , Houston, TX, 77030, USA

12. Department of Molecular and Human Genetics, Baylor College of Medicine , Houston, TX, 77030, USA

13. Department of Statistics and Data Science, The Hebrew University of Jerusalem , Jerusalem, Israel

14. Center for Bioethics, Harvard Medical School , Boston, MA, USA

15. Department of Psychiatry, Massachusetts General Hospital , Boston, MA, USA

16. Departments of Psychiatry and Molecular Medicine, Zucker School of Medicine at Hofstra/Northwell , Hempstead, NY, USA

17. Institute of Behavioral Science, Feinstein Institutes for Medical Research , Manhasset, NY, USA

18. Division of Psychiatry Research, Zucker Hillside Hospital , Glen Oaks, NY, USA

Abstract

ABSTRACT Recent advances in developing polygenic scores have made it possible to screen embryos for common, complex conditions and traits. Polygenic embryo screening (PES) is currently offered commercially, and though there has been much recent media and academic coverage, reproductive specialists’ points of view have not yet been prominent in these discussions. We convened a roundtable of multidisciplinary experts, including reproductive specialists to discuss PES and its implications. In this Opinion, we describe four clinically relevant issues associated with the use of PES that have not yet been discussed in the literature and warrant consideration.

Funder

National Human Genome Research Institute of the National Institutes of Health

NIH

Publisher

Oxford University Press (OUP)

Subject

Obstetrics and Gynecology,Rehabilitation,Reproductive Medicine

Reference32 articles.

1. Re-conceptualizing risk in genetic counseling: implications for clinical practice;Austin;J Genet Counsel,2010

2. A new kind of embryo genetics screening makes big promises on little evidence;Davis;Slate,2021

3. ART in Europe, 2016: results generated from European registries by ESHRE;Wyns;Hum Reprod Open,2020

4. Helping doctors and patients make sense of health statistics;Gigerenzer;Psychol Sci Public Interest,2007

5. Identification of common genetic risk variants for autism spectrum disorder;Grove;Nat Genet,2019

Cited by 13 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Polygenic embryo screening: quo vadis?;Journal of Assisted Reproduction and Genetics;2024-06-15

2. Screening embryos for polygenic disease risk: a review of epidemiological, clinical, and ethical considerations;Human Reproduction Update;2024-05-28

3. Public Attitudes, Interests, and Concerns Regarding Polygenic Embryo Screening;JAMA Network Open;2024-05-14

4. Polygenic Risk Scores (PRS);Reference Module in Life Sciences;2024

5. The expansion of genomic precision medicine to prenatal care;Comprehensive Precision Medicine;2024

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3