Cumulus cells surrounding oocytes with high developmental competence exhibit down-regulation of phosphoinositol 1,3 kinase/protein kinase B (PI3K/AKT) signalling genes involved in proliferation and survival-Reference-Cited by-同舟云学术

Cumulus cells surrounding oocytes with high developmental competence exhibit down-regulation of phosphoinositol 1,3 kinase/protein kinase B (PI3K/AKT) signalling genes involved in proliferation and survival

Published:2017-10-26 Issue:12 Volume:32 Page:2474-2484
ISSN:0268-1161
Container-title:Human Reproduction
language:en
Short-container-title:

Author:

Artini P G¹,Tatone C²,Sperduti S³,D’Aurora M³⁴,Franchi S³⁴,Di Emidio G²,Ciriminna R⁵,Vento M⁶,Di Pietro C⁷,Stuppia L³⁴,Gatta V³⁴,

Affiliation:

1. Department of Clinical and Experimental Medicine, Division of Obstetrics and Gynecology Oncology, University of Pisa, Via Savi 10, 56126 Pisa, Italy

2. Department of Life, Health and Environmental Sciences, University of L’Aquila, Piazzale Salvatore Tommasi 1, 67100 L’Aquila, Italy

3. Functional Genetics Unit, Center of Excellence on Aging (Ce.S.I.-Met), Via Dei Vestini 31, 66100 Chieti, Italy

4. Department of Psychological, Health and Territorial Sciences, School of Medicine and Health Sciences, ‘G.d’Annunzio’ University, Via Dei Vestini 31, 66100 Chieti, Italy

5. AMBRA-Associazione Medici e Biologi per la Riproduzione Assistita, Palermo, Italy

6. IVF Unit, Cannizzaro Hospital, Catania, Italy

7. Department of Biomedical Sciences and Biotechnolgy, Section of Biology and Genetics G. Sichel, University of Catania, Via S.Sofia, 87, 95123 Catania, Italy

Funder

Merck Serono S.p.A. an affiliate of Merck KGaA, Darmstadt, Germany

Publisher

Oxford University Press (OUP)

Subject

Obstetrics and Gynecology,Rehabilitation,Reproductive Medicine

Link

http://academic.oup.com/humrep/article-pdf/32/12/2474/24265368/dex320.pdf

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2. Use of both cumulus cells’ transcriptomic markers and zona pellucida birefringence to select developmentally competent oocytes in human assisted reproductive technologies;Assidi;BMC Genomics,2015

3. Biomarkers of human oocyte developmental competence expressed in cumulus cells before ICSI: a preliminary study;Assidi;J Assist Reprod Genet,2011