DMRT1 repression using a novel approach to genetic manipulation induces testicular dysgenesis in human fetal gonads

Author:

Macdonald Joni1,Kilcoyne Karen R1,Sharpe Richard M1,Kavanagh Áine1,Anderson Richard A1,Brown Pamela1,Smith Lee B12,Jørgensen Anne3,Mitchell Rod T14ORCID

Affiliation:

1. MRC Centre for Reproductive Health, The Queen’s Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh, Scotland, UK

2. School of Environmental and Life Sciences, Faculty of Science, University of Newcastle, Callaghan, NSW, Australia

3. University Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark

4. Edinburgh Royal Hospital for Sick Children, 9 Sciennes Road, Edinburgh, Scotland, UK

Funder

Wellcome Trust Intermediate Clinical Fellowship

MRC

MRC Centre

Publisher

Oxford University Press (OUP)

Subject

Obstetrics and Gynecology,Rehabilitation,Reproductive Medicine

Reference49 articles.

1. FGFR2 mutation in 46,XY sex reversal with craniosynostosis;Bagheri-Fam;Hum Mol Genet,2015

2. Testis cord differentiation after the sex determination stage is independent of Sox9 but fails in the combined absence of Sox9 and Sox8;Barrionuevo;Dev Biol,2009

3. Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration;Barrionuevo;Elife,2016

4. Increased expression of the FIGLA transcription factor is associated with primordial follicle formation in the human fetal ovary;Bayne;Mol Hum Reprod,2004

5. Deletion 9p and sex reversal;Bennett;J Med Genet,1993

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