A linear energy transfer distributions computation method for inhomogeneous medium by using the water equivalent ratio approximation

Author:

Yan Nan12ORCID,Wu Chao3,Zhou Yun12,Liao Wentao12,Liu Junya12,Pu Yuehu3

Affiliation:

1. Chinese Academy of Sciences Shanghai Institute of Applied Physics, , Shanghai 201800 , China

2. University of Chinese Academy of Sciences , Beijing 100049 , China

3. West China Hospital, Sichuan University Medical Equipment Innovation Research Center, West China School of Medicine, Med+X Center for Manufacturing, , Chengdu 610041 , China

Abstract

Abstract Dose-averaged linear energy transfer (LET), LETd is widely used in proton therapy. Compared with analytical models, Monte Carlo (MC) simulations are more accurate in obtaining LETd distributions, but they are time-consuming. This study used the 3D LETd distributions of proton beam spots in water by MC simulations as a benchmark data set. Subsequently, by combining the water equivalent ratio of various human tissues, the 3D LETd distributions of clinical cases could be quickly obtained. Our method was applied to a single spot of 160 MeV proton beam in a water-bone phantom and a pelvic case. We also computed the 3D LETd distributions for multiple proton beam spots in the pelvic case and a lung case. The results of our method were compared with the results of MC simulations, demonstrating that our method can rapidly provide 3D LETd distributions of clinical cases with acceptable differences from MC simulations.

Funder

National Key Research and Development Program of China

Publisher

Oxford University Press (OUP)

Subject

Public Health, Environmental and Occupational Health,Radiology, Nuclear Medicine and imaging,General Medicine,Radiation,Radiological and Ultrasound Technology

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