Comparison of biological weighting functions to estimate the microdosimetric RBE in BNCT

Author:

Selva Anna1ORCID,Bianchi Anna1ORCID,Bellan Luca1,Fagotti Enrico1,Pisent Andrea1,Conte Valeria1

Affiliation:

1. Istituto Nazionale di Fisica Nucleare INFN, Laboratori Nazionali di Legnaro , viale dell’Università 2, Legnaro, Italy

Abstract

Abstract In the framework of the MUNES project, a prototype accelerator-based thermal neutron source was developed and installed at the Legnaro National Laboratories of INFN. The microdosimetric characterization of this radiation field was performed with a Tissue-Equivalent Proportional Counter with interchangeable cathode walls, either doped with 100 ppm of 10B or without boron doping. A suitable subtraction procedure allowed to discriminate the gamma, neutron and BNC dose components (Selva et al., 2022, Appl. Radiat. Isot. 182, 110144). The measured microdosimetric spectra can be weighted with a biological weighting function to estimate the Relative Biological Effectiveness of the radiation field, for the purpose of intercomparison between different thermal neutron sources. This work compares, therefore, the biological doses resulting from four different weighting functions applied to the same initial microdosimetric spectrum, discussing strengths and limitations of each of them.

Funder

Fifth Scientific Commission of the Italian Istituto Nazionale di Fisica Nucleare

Publisher

Oxford University Press (OUP)

Subject

Public Health, Environmental and Occupational Health,Radiology, Nuclear Medicine and imaging,General Medicine,Radiation,Radiological and Ultrasound Technology

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