Primary COVID-19 vaccine cycle and booster doses efficacy: analysis of Italian nationwide vaccination campaign

Author:

Mattiuzzi Camilla1,Lippi Giuseppe2

Affiliation:

1. Service of Clinical Governance, Provincial Agency for Social and Sanitary Services, Trento, Italy

2. Section of Clinical Biochemistry and School of Medicine, University of Verona, Italy

Abstract

Abstract We provide here an updated analysis of primary COVID-19 vaccination and vaccine booster doses efficacy, emerging from the ongoing Italian nationwide COVID-19 vaccination campaign. Primary COVID-19 vaccination efficacy was 76-92% within 6 months, decreasing to 34-80% after 6 months. Administration of vaccine booster doses decreased SARS-CoV-2 infections by 65%, COVID-19 related hospitalizations and deaths by 69% and 97% compared to vaccine efficacy after 6 months, but also decreased SARS-CoV-2 infections by 39% compared to vaccine efficacy within 6 months. These results suggest that COVID-19 vaccine booster doses are important for restoring vaccine efficacy and further limiting virus circulation.

Publisher

Oxford University Press (OUP)

Subject

Public Health, Environmental and Occupational Health

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