Atopic diseases and airway-related symptoms in Bavarian pre-schoolers: determinants and association with immunization
Author:
Korbely Christine123ORCID, Weinberger Alisa3, Kutzora Susanne3ORCID, Huß Jonas3, Hendrowarsito Lana3, Nennstiel Uta4, Heißenhuber Annette4, Herr Caroline35, Heinze Stefanie35, Doerk Wiltrud Angelika, Pfister Rosemarie, Sittig Winfried, Strauch Heidi, Thamm Anita, Wunder Tatjana, Frieß-Hesse Franziska, Lang Dagmar, Rudolph Roland, Schmid Gudrun, Winter Isabella, Bockmann Christine, Gampenrieder Margot, Motzet Elisabeth, Schneider Traudl, Tontsch Gerlinde, Woelk Sylvia, Kranebitter Heidi, Mayrhofer Gertraud, Rohrhirsch Brigitte, Weise Luisa, Wolf Kornelia, Baranek Gitte, Koch-Singer Maximilian, Kühnel Ladan, Baghi Otmar, von Bayer Rüdiger, Kries Gabriele, Bolte Hermann, Fromme Annette, Heißenhuber Lana, Hendrowarsito Caroline, Herr Martina, Kohlhuber Joseph, Kuhn Bernhard, Liebl Anja, Lüders Nicole, Meyer Christine, Mitschek Gabriele, Morlock Michael, Mosetter Uta, Nennstiel-Ratzel Dorothee, Twardella Manfred, Wildner Angelika,
Affiliation:
1. Institute for Medical Informatics, Biometry and Epidemiology (IBE) at the Ludwig-Maximilians-Universität München, Munich, Germany 2. Pettenkofer School of Public Health, Munich, Germany 3. Department of Occupational and Environmental Health/Epidemiology, Bavarian Health and Food Safety Authority, Munich, Germany 4. Bavarian Health and Food Safety Authority (LGL), Oberschleißheim, Germany 5. Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Hospital of the University of Munich, Munich, Germany
Abstract
Abstract
Background
Atopic diseases are among the most common chronic conditions in childhood. Causes of allergies are manifold. The aim of this paper is to evaluate risk factors for atopic diseases and unremitting wheeze and to examine if there is an association between measles, mumps and rubella (MMR) vaccination and atopic dermatitis, asthma and unremitting wheeze in Bavarian pre-schoolers.
Methods
Parents filled out a questionnaire on children’s health and environmental and socioeconomic factors. The questionnaire was administered within the Health Monitoring Units in a cross-sectional study in Bavaria, Germany (2014/2015). Data on vaccinations were obtained via the School Entrance Examination, a mandatory examination for pre-school children in Bavaria. Rates of influential factors of atopic diseases and wheeze, MMR and DTP (diphtheria, pertussis and tetanus) vaccination were calculated for all children stratified by health outcomes. To examine if there is an association between MMR vaccination and health outcomes, a multiple logistic regression analysis was performed.
Results
Data were available for 3237 individuals. Symptoms and diseases were more frequent in boys. Higher parental education was associated with a higher prevalence of atopic dermatitis. There were no significant associations between any of the health outcome groups and MMR vaccination in the multiple logistic regression models with adjustment for potential confounders.
Conclusions
The present study is in line with the current state of research that MMR vaccination is not associated with atopic diseases.
Publisher
Oxford University Press (OUP)
Subject
Public Health, Environmental and Occupational Health
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