When recognizing the cultural political agency of Black women and girls from diverse racial and ethnic, gender, sexual, and socioeconomic backgrounds and geographical locations, it is argued that intersectionality is a contributing factor in the mitigation of educational inequality. Intersectionality as an analytical framework helps education researchers, policymakers, and practitioners better understand how race and gender intersect to derive varying amounts of penalty and privilege. Race, class, and gender are emblematic of the three systems of oppression that most profoundly shape Black girls at the personal, community, and social structural levels of institutions. These three systems interlock to penalize some students in schools while privileging other students. The intent of theoretically framing and analyzing educational problems and issues from an intersectional perspective is to better comprehend how race and gender overlap to shape (a) educational policy and discourse, (b) relationships in schools, and (c) students’ identities and experiences in educational contexts. With Black girls at the center of analysis, educational theorists and activists may be able to better understand how politics of domination are organized along other axes such as ethnicity, language, sexuality, age, citizenship status, and religion within and across school sites. Intersectionality as a theoretical framework is informed by a variety of standpoint theories and emancipatory projects, including Afrocentrism, Black feminism and womanism, critical race theory, queer theory, radical Marxism, critical pedagogy, and grassroots’ organizing efforts led by Black, Indigenous, and other women of color throughout US history and across the diaspora.