Evidence-based practice (EBP) is an educational and practice paradigm that includes a series of predetermined steps aimed at helping practitioners and agency administrators identify, select, and implement efficacious interventions for clients. This entry identifies definitions of EBP and traces the evolution of EBP from its origins in the medical profession to its current application in social work. Essential steps in the process of EBP and challenges associated with applying EBP to social work practice, education, and research are noted.