The modern-day cultivated and highly consumed tomato has come a long way from its ancestor(s), which were in the wild and not palatable. Breeding strategies made the difference in making desirable food, including tomato, available for human consumption. However, like other horticultural produce, the shelf life of tomato is short, which results in losses that can reach almost 50% of the produce, more so in developing countries than in countries with advanced technologies and better infrastructure. Food security concerns are real, especially taking into consideration that the population explosion anticipated by 2050 will require more food production and the production of more nutritious food, which applies as much to the tomato crop as the other crops. Today’s consumer has become aware and is looking for nutritious foods for a healthful and long life. Little was done until recently to generate nutritionally enhanced produce including fruits/vegetables. Also, extreme environments add to plant stress and impact yield and nutritional quality of produce. Recent developments in understandings of the plant/fruit genetics and progress made in developing genetic engineering technologies, including the use of CRISPR-Cas9, raise hopes that a better tomato with a high dose of nutrition and longer-lasting quality will become a reality.