Exploratory Study of the Effectiveness of Granulocyte and Monocyte Adsorptive Apheresis Before Initiation of Steroids in Patients With Active Ulcerative Colitis (EXPECT Study): A Multicenter Prospective Clinical Trial-Reference-Cited by-同舟云学术

Exploratory Study of the Effectiveness of Granulocyte and Monocyte Adsorptive Apheresis Before Initiation of Steroids in Patients With Active Ulcerative Colitis (EXPECT Study): A Multicenter Prospective Clinical Trial

Published:2020-09-23 Issue:4 Volume:2 Page:
ISSN:2631-827X
Container-title:Crohn's & Colitis 360
language:en
Short-container-title:

Author:

Kakimoto Kazuki¹^ORCID,Matsuura Minoru²,Fukuchi Takumi³,Hongo Hitoshi⁴,Kimura Tsuguhiro⁴,Aoyama Nobuo⁵,Okuda Yorihide⁶,Aomatsu Kazuki⁷,Kamata Noriko⁸,Yokoyama Yoko⁹,Mizuno Chiemi¹⁰,Inoue Takuya¹,Miyazaki Takako¹,Nakamura Shiro¹,Higuchi Kazuhide¹,Nakase Hiroshi¹¹

Affiliation:

1. 2nd Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan

2. Department of Gastroenterology and Hepatology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan

3. Department of Gastroenterology and Hepatology, Iseikai Hospital, Osaka, Osaka, Japan

4. Department of Gastroenterology, Fujita Gastroenterological Hospital, Takatsuki, Osaka, Japan

5. Department of Gastroenterology, Gastrointestinal Endoscopy and IBD Center, Aoyama Medical Clinic, Kobe, Hyogo, Japan

6. Department of Gastroenterology, Otemae Hospital, Osaka, Osaka, Japan

7. Department of Gastroenterology, Izumiotsu Municipal Hospital, Izumiotsu, Osaka, Japan

8. Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Osaka, Japan

9. Department of Intestinal Inflammation Research, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan

10. Department of Gastroenterology and Hepatology, Saiseikai Suita Hospital, Suita, Osaka, Japan

11. Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan

Abstract

Abstract Background Granulocyte and monocyte adsorptive apheresis (GMA) has been used for therapy of steroid-dependent/refractory ulcerative colitis (UC). The aim of this study was to investigate the effectiveness of GMA in UC patients not receiving steroids. Methods We conducted a single-arm, open-label, and multicenter prospective clinical trial. UC patients who had insufficient responses to 5-aminosalicylic acid received GMA twice a week for 5 weeks. Results The response rate of all patients was 58.2% (39/67). Of the 39 patients who achieved a response, 74.4% achieved endoscopically confirmed mucosal healing. Conclusions GMA shows effectiveness in inducing remission in UC patients not receiving steroid.

Funder

Health and Labor Sciences Research

Ministry of Health, Labor and Welfare of Japan

Japan Society for the Promotion of Science

Grants-in-Aid for Scientific Research

Publisher

Oxford University Press (OUP)

Subject

General Earth and Planetary Sciences,General Engineering,General Environmental Science

Link

http://academic.oup.com/crohnscolitis360/advance-article-pdf/doi/10.1093/crocol/otaa073/33781922/otaa073.pdf

Reference32 articles.