Post-inflammatory Abdominal Pain in Patients with Inflammatory Bowel Disease During Remission: A Comprehensive Review

Author:

Takahashi Kazuya12,Khwaja Iman Geelani1,Schreyer Jocelyn Rachel1,Bulmer David3,Peiris Madusha1ORCID,Terai Shuji2,Aziz Qasim1

Affiliation:

1. Centre for Neuroscience, Surgery and Trauma, Wingate Institute of Neurogastroenterology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

2. Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan

3. Department of Pharmacology, University of Cambridge, Cambridge, UK

Abstract

Abstract Patients with inflammatory bowel disease often experience ongoing pain even after achieving mucosal healing (i.e., post-inflammatory pain). Factors related to the brain–gut axis, such as peripheral and central sensitization, altered sympatho-vagal balance, hypothalamic–pituitary–adrenal axis activation, and psychosocial factors, play a significant role in the development of post-inflammatory pain. A comprehensive study investigating the interaction between multiple predisposing factors, including clinical psycho-physiological phenotypes, molecular mechanisms, and multi-omics data, is still needed to fully understand the complex mechanism of post-inflammatory pain. Furthermore, current treatment options are limited and new treatments consistent with the underlying pathophysiology are needed to improve clinical outcomes.

Publisher

Oxford University Press (OUP)

Subject

General Earth and Planetary Sciences,General Engineering,General Environmental Science

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