Population pharmacokinetic analysis of ropivacaine and its metabolite 2′,6′-pipecoloxylidide from pooled data in neonates, infants, and children

Author:

Aarons L.,Sadler B.,Pitsiu M.,Sjövall J.,Henriksson J.,Molnár V.

Funder

AstraZeneca R&D Sodertalje

Publisher

Elsevier BV

Subject

Anesthesiology and Pain Medicine

Reference40 articles.

1. Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine, and placebo in volunteers;Knudsen;Br J Anaesth,1997

2. Cardiac resuscitation after incremental overdosage with lidocaine, bupivacaine, levobupivacaine, and ropivacaine in anesthetized dogs;Groban;Anesth Analg,2001

3. The effect of continuous lumbar epidural infusion of ropivacaine (0.1%, 0.2%, and 0.3%) and 0.25% bupivacaine on sensory and motor block in volunteers: a double-blind study;Zaric;Reg Anesth,1996

4. Ropivacaine, a new amide-type local anesthetic agent, is metabolized by cytochromes P450 1A and 3A in human liver microsomes;Ekström;Drug Metab Dispos,1996

5. Metabolism and excretion of ropivacaine in humans;Halldin;Drug Metab Dispos,1996

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