Sphincter-saving surgery after neoadjuvant therapy for ultra-low rectal cancer where abdominoperineal resection was indicated: 10-year results of the GRECCAR 1 trial-Reference-Cited by-同舟云学术

Sphincter-saving surgery after neoadjuvant therapy for ultra-low rectal cancer where abdominoperineal resection was indicated: 10-year results of the GRECCAR 1 trial

Published:2020-12-16 Issue:1 Volume:108 Page:10-13
ISSN:0007-1323
Container-title:British Journal of Surgery
language:en
Short-container-title:

Author:

Rouanet P¹^ORCID,Rivoire M²,Gourgou S³,Lelong B⁴^ORCID,Rullier E⁵,Jafari M⁶,Mineur L⁷,Pocard M⁸,Faucheron J L⁹^ORCID,Dravet F¹⁰,Pezet D¹¹,Fabre J M¹²,Bresler L¹³,Balosso J¹⁴,Lemanski C¹⁵

Affiliation:

1. Department of Surgical Oncology, Institut Régional du Cancer de Montpellier—Val d’Aurelle, Montpellier, France

2. Department of Surgical Oncology, Centre Léon Berard, Lyon, France

3. Biometrics Unit, Montpellier Cancer Institute, Montpellier, France

4. Department of Surgical Oncology, Institut Paoli Calmettes, Marseille, France

5. Colorectal Department, Centre Hospitalier Universitaire Bordeaux, Bordeaux, France

6. Department of Surgical Oncology, Centre Oscar Lambret, Lille, France

7. Department of Radiation Oncology, Institut Sainte Catherine, Avignon, France

8. Department of Surgical Oncology, Gustave Roussy (Hôpital Lariboisière Assistance Publique–Hôpitaux de Paris), Paris, France

9. Colorectal Department, Centre Hospitalier Universitaire Grenoble, Grenoble, France

10. Department of Surgical Oncology, Centre René Gauducheau, Nantes, France

11. Colorectal Department, Centre Hospitalier Universitaire Clermont-Ferrand, Clermont-Ferrand, France

12. Colorectal Department, Centre Hospitalier Universitaire Montpellier, Montpellier, France

13. Colorectal Department, Centre Hospitalier Universitaire Nancy, Nancy, France

14. Department of Radiotherapy, Centre Hospitalier Universitaire Grenoble, Grenoble, France

15. Department of Radiotherapy, Institut Régional du Cancer de Montpellier—Val d’Aurelle, Montpellier, France

Abstract

This phase III trial included patients with ultra-low rectal adenocarcinoma that initially required abdominoperineal resection. The surgical decision was based on clinical tumour status after preoperative treatment. The overall sphincter-saving resection rate was 85 per cent, with 72 per cent rate of intersphincteric resection. Long-term results showed that changing the initial abdominoperineal resection indication into a sphincter-saving resection according to tumoral response is oncologically safe. Saving the sphincter

Publisher

Oxford University Press (OUP)

Subject

Surgery

Link

https://academic.oup.com/bjs/article-pdf/108/1/10/41823569/znaa010.pdf

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